Mechanisms of flunarizine-induced vasodilation in the rabbit mesenteric artery.
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چکیده
منابع مشابه
Mechanisms of flunarizine-induced vasodilation in the rabbit mesenteric artery.
The vasodilating effects of flunarizine on smooth muscle strips of rabbit mesenteric artery have been investigated and compared with those of nifedipine. Flunarizine (30-300 nM) dose-dependently inhibited Ca2+-induced contractions in Ca2+-free solution containing 100 mM K+. Double reciprocal analysis showed that this inhibition was either competitive at low concentrations (30-100 nM; nifedipine...
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The mechanism ofthe Bat+-induced contraction was investigated using intact and saponin-treated skinned smooth muscle (skinned muscle) strips of the rabbit mesenteric artery . After depletion of Ca21 stored in the caffeinesensitive site, >0 .65 mM Ba2+ evoked contraction in muscle strips depolarized with 128 mM K+ in Cat+-free solution in a dose-dependent fashion, and the ED50 values for Ca2' an...
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The mechanism of the Ba2+-induced contraction was investigated using intact and saponin-treated skinned smooth muscle (skinned muscle) strips of the rabbit mesenteric artery. After depletion of Ca2+ stored in the caffeine-sensitive site, greater than 0.65 mM Ba2+ evoked contraction in muscle strips depolarized with 128 mM K+ in Ca2+-free solution in a dose-dependent fashion, and the ED50 values...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1987
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.61.3.446